One of the most basic things to know when using any probe is “what is the maximum voltage the device can safely measure?” The answer isn’t as straightforward as you might imagine, it requires understanding several key probe specifications as well as the nature of your signal.
Single-ended Range
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Figure 1. Single-ended range is measured voltage input to ground.
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Everyone is pretty familiar with single-ended range: that's the maximum safe voltage input to ground, shown in Figure 1. Ground is directly tied to oscilloscope ground, which is tied to building ground. Therefore, when measuring voltage within this range using a single-ended probe, the ground connection cannot be a floating voltage, or you could damage the probe, the DUT, the oscilloscope...maybe yourself, as well. Single-ended voltage must be a grounded voltage on your board or something that could be tied to ground.